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| CAS:60189‑34‑6:Tetracosactide acetate | |
| Tetracosactide is the N‑terminal 24‑mer active fragment of native adrenocorticotropic hormone (ACTH), containing all core domains for receptor binding and biological activity. It specifically binds to MC2 receptors on adrenocortical cell membrane, activates the cAMP signaling pathway, and dose‑dependently stimulates adrenal cortex to secrete glucocorticoids, mineralocorticoids and androgens, with physiological activity consistent with full‑length ACTH. Clinically used for adrenal cortical function stimulation tests, and also for replacement therapy of autoimmune and inflammatory diseases. The acetate form has good water solubility for convenient formulation and administration. | |
| 95%/98%/99% | |
| C₁₃₆H₂₁₀N₄₀O₃₁S | |
| 2933.4, higher for acetate form | |
| Linear 24‑mer, acetate salt |
| Function Tags (comma-separated) | ||||||||
| Tetracosactide acetate; ACTH (1-24) | Adrenal cortex stimulation, Glucocorticoid secretion, Adrenal function test, Anti-inflammatory anti-immune, Endocrine peptide, Diagnostic reagent | ACTH N-terminal active fragment with native amino acid sequence | 2932.58 | 2933.4 | 24 |
| Long-term Storage | Short-term Storage | ||||
| PEP-TET001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 48h at 4℃; rapidly degraded by peptidases at room temperature with sharp activity decline,**Good water solubility, freely soluble in water and physiological buffer**. Native linear peptide, N-terminal prone to aminopeptidase cleavage and inactivation | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-TET001 | ACTH active fragment that specifically stimulates adrenal cortical hormone secretion, for adrenal function testing and anti-inflammatory therapy | Tetracosactide specifically binds to melanocortin 2 receptors (MC2R) on the cell membrane of adrenal cortical zona fasciculata and zona reticularis, activates the G protein-mediated adenylate cyclase / cAMP / PKA signaling pathway, rapidly promotes the conversion of cholesterol to pregnenolone, and dose-dependently stimulates the synthesis and secretion of glucocorticoids (cortisol), mineralocorticoids (aldosterone) and androgens. It retains all physiological activities of native ACTH, with smaller molecular weight and lower immunogenicity. Clinically, it is mainly used for adrenal cortical function stimulation tests to evaluate adrenal reserve function; it can also be used short-term for replacement therapy of autoimmune and inflammatory diseases. | Adrenal function testing, Endocrine physiology research, Autoimmune disease therapy, Inflammatory diseases, Hypothalamic-pituitary-adrenal axis, Peptide diagnostic reagents | Melanocortin 2 Receptor (MC2R); cAMP/PKA signaling pathway; Adrenal cortical hormone synthesis and secretion pathway |
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